Resume

 

          Folic acid (FA) is an electroactive molecule belonging to the water-soluble vitamin class. It is presented as a vital biological compound for human health. For that reason, an accurate method for the detection of FA is necessary.

         Most literature studies on the determination and quantification of FA use fluorimetry, capillary electrophoresis, and spectrophotometry. All of these techniques are generally expensive, and show low sensitivity. Therefore, the use of alternative new techniques is supposed to be very useful. Recently, electrochemical methods, and especially voltammetry, have attracted attention because of their advantages such as sensitivity, simplicity, low cost, and selectivity of electroactive species. Besides, the use of the electrochemical approach for FA detection is generally promising since FA is an electrochemically active compound. Among the many potentially useful electrodes, screen-printed electrodes offer many advantages for electrochemical sensors, such as low cost, portability, miniaturization, and ease of chemical modification.

         In order to obtain electrochemical sensors and biosensors, many nanomaterials like Graphene, TMDCs, gold and silver NP, nanocomposite… have already been employed. Currently, due to their unique structures and distinguishing properties, 2D TMDC compounds have been widely used in energy storage, sensor, biomedicine, and many other important areas. Significantly, molybdenum disulfide (MoS2), belonging to the 2D TMDC family, attracted attention due to its graphene-like structure as well as a diversity of excellent optical, electrical, mechanical, and catalytic properties.

The main objective of this work is to take advantage of SPE tools and of Au-MoS2 nanocomposite, combining them in a biosensor to specify folic acid quantities.

        Our work proposes to precisely tune a 2D material consisting of molybdenum disulphide nanosheets (MoS2 NS) decorated with gold nanoparticles (Au NP), which were deposited on a screen-printed carbon electrode (SPCE). Thus, this composite is well adapted for the detection of the level of Folic acid using cyclic voltammetric tests to check the efficiency of this sensor for detection at low traces.

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