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TUN-KSA Project 2012-2014

Lanthanide-doped Oxide Nanoparticles for Multi-modal Molecular Imaging Agents

PARTNER

Prof. Nabil Maalej

Center of Excellence of Nanotechnology CENT (KFUPM)

          We synthesized Gd 2 O 3 and Gd 2 O 3 doped Europium (2-10%) nanoplatelets using the polyol chemical method. The synthesized nanoplatelets were characterized by XRD, FESEM, TEM and EDX techniques. The optical properties of the synthesized nanoplatelets were investigated by photoluminescence spectroscopy. We also studied the MRI contrast enhancement of T1 relaxivity using 3 Tesla magnetic resonance (MRI) machine. The XRD for Gd 2 O 3 revealed a cubic crystalline structure. The XRD of Gd 2 O 3 :Eu 3+ nanoplatelets were highly consistent with Gd 2 O 3 indicating the total incorporation of the Eu 3+ ions in the Gd 2 O 3 matrix.

 

        The Europium doping of Gd 2 O 3 produced red luminescence around 612 nm corresponding to the radiative transitions from the europium excited state 5 D 0 to the 7 F 2. The photoluminescence was maximum at 5 % Eu doping concentration. The stimulated CIE chromaticity coordinates were also calculated. Judd-Ofelt analysis was used to obtain the radiative properties of the sample from the emission spectra. The MRI contrast enhancement due to Gd 2 O 3 was compared to DOTAREM commercial contrast agent at similar concentration of gadolinium oxide and provided similar contrast enhancement. The incorporation of Europium, however, decreased the MRI contrast due to replacement of gadolinium by Europium.

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