Biography
Prof. Dr. Clara Viñas Teixidor graduated in Chemistry at the Universitat Autònoma de Barcelona and later in Pharmacy at the Universitat de Barcelona. She worked as a pre-doctoral student at the Prof. Rudolph’s laboratory at The University of Michigan for a year. She is a Research Professor at the Institut de Ciència de Materials de Barcelona that belongs to the Spanish Council for Scientific Research since 2006. Previously, she worked in an industry dedicated to recovery of industrial residual waters, and at public institution involved in food science analysis as well as environmental control.
Her fields of research involve synthesis and derivatisation of boron clusters to be applied in medicine and biosensors, among others.
PAQ-Collabora Project
Development of New kit for Latent Fingerprint detection and Authentication "KIDAEM"
PAQ-Collabora Project
Development of New kit for Latent Fingerprint detection and Authentication "KIDAEM"
PAQ-Collabora Project
Development of New kit for Latent Fingerprint detection and Authentication "KIDAEM"
PROJECT PARTNERS
GEOGLOB-Lab Faculty of Sciences of Sfax
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LATIS-Lab National School of Engineers of Sousse
CEM-Lab National School of Engineers of Sfax
SOGIMEL Private Company
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PROJECT PARTNERS
GEOGLOB-Lab Faculty of Sciences of Sfax
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LATIS-Lab National School of Engineers of Sousse
CEM-Lab National School of Engineers of Sfax
SOGIMEL Private Company
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RESUME
RESUME
Registration
PROJECT NEWS
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04/04/2019 Call for POSTDOC recrutment
30/03/2019 Signature of the financial support memorandum by the minister of HER
22/03/2019 Coaching session @ Ministry
01/03/2019 First meeting of project members
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Plenary Speaker
Professor Abdul K. Parchur
Biography:
Abdul K. Parchur received the M.Sc. and Ph.D. degrees in physics from Dr. Hari Singh Gour University, India, in 2010. He is currently a Researcher with the Department of Biomedical Engineering, The Medical College of Wisconsin, Milwaukee, WI, USA. His research involves the development of image-guided theranostic nanoparticles for preclinical therapeutic interventions. He has authored or co-authored over 20 peer-reviewed publication and three book chapters that have been cited more than 1300 times with an h-factor of 18. His research interests span the field of nanomedicine with a special emphasis on plasmonic nanomaterials, cancer theranostics, nearinfrared imaging, magnetic resonance imaging, and computed tomography imaging.
Image-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis
Abdul K. Parchur
Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226
Email : aparchur@outlook.com
We report sub-100 nm optical/magnetic resonance (MR)/X-ray contrast-bearing theranostic nanoparticles (TNPs) for interventional image-guided photothermal therapy (PTT) of solid tumors. TNPs were composed of Au@Gd2O3:Ln (Ln = Yb/Er) with X-ray contrast (∼486 HU; 1014 NPs/mL, 0.167 nM) and MR contrast (∼1.1 × 108 mM–1 S–1 at 9.4 T field strength). Although TNPs are deposited in tumors following systemic administration via enhanced permeation and retention effect, the delivered dose to tumors is typically low; this can adversely impact the efficacy of PTT. To overcome this limitation, we investigated the feasibility of site-selective hepatic image-guided delivery of TNPs in rats bearing colorectal liver metastasis (CRLM). The mesenteric vein of tumor-bearing rats was catheterized, and TNPs were infused into the liver by accessing the portal vein for site-selective delivery. The uptake of TNPs with hepatic delivery was compared with systemic administration. MR imaging confirmed that delivery via the hepatic portal vein can double the CRLM tumor-to-liver contrast compared with systemic administration. Photothermal ablation was performed by inserting a 100 μm fiber-optic carrying 808 nm light via a JB1, 3-French catheter for 3 min under DynaCT image guidance. Histological analysis revealed that the thermal damage was largely confined to the tumor region with minimal damage to the adjacent liver tissue. Transmission electron microscopy imaging validated the stability of core–shell structure of TNPs in vivo pre- and post-PTT. TNPs comprising Gd-shell-coated Au nanorods can be effectively employed for the site-directed PTT of CRLM by leveraging interventional radiology methods.
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